This is Masjid Qiblatain (Mosque of the Two Qiblas). It is historically important to Muslims as this is where in Rajjab 2 AH the revelation of the Quran came to change the direction of the Qibla from Bait-al-Maqdis in Jerusalem to the Ka’bah in Makkah.
During Dhuhr prayer or it was said that it was Asr, the Prophet (peace and blessings of Allah be on him) had led his Companions in praying two rak’ahs, when he was commanded to face towards the Ka’bah by the following revelation in the Quran in Surah al-Baqarah: “Verily, We have seen the turning of your (Muhammed’s) face towards the heaven. Surely, We shall turn you to a Qiblah (prayer direction) that shall please you, so turn your face in the direction of Al-Masjid Al-Haram (at Makkah). And wheresoever you people are, turn your faces (in prayer) in that direction.” [2:144 ]

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